The Effect of Commencing Time of Diuretic Load on the Contractile Function of Rat Urinary Bladder

Aims of Study We previously reported that diuresis since before bladder outlet obstruction (BOO) has resulted in an increase in bladder mass and wall thickness resulting in an increase in contractile strength. This augmented contractile strength of bladder smooth muscle resulted in protection against the contractile dysfunction secondary to BOO. However, it has been still unclear that the effect of commencing time of diuretic load on the bladder smooth muscle function. The aim of this study is to determine the effect of commencing time of diuretic load on the contractile ability of rat bladder smooth muscle with BOO.